Definition of organic anion transporters, sodiumindependent in the dictionary. Organic anion transporters and their implications in. Slc26a11 sodiumindependent sulfate anion transporter homo. Meaning of organic anion transporters, sodiumindependent. Molybdate transport through the plant sulfate transporter shst1.
These primary transporters are enzymes that convert energy from various sourcesincluding adenosine triphosphate atp, sunlight, and other redox reactionsto potential energy stored in an electrochemical gradient. Endocrinology, volume 142, issue 10, 1 october 2001, pages 43394348. Transport of estrone 3sulfate mediated by organic anion transporter. Transporters known to play a role in ion transport at the bcsfb but are not. Organic anion transporter f definition of organic anion. Many organisms including bacillus subtilis, synechocystis sp, saccharomyces cerevisiae, arabidopsis thaliana and caenorhabditis elegans possess multiple sulp family paralogues. Transporter function and protein expression were assessed in oatp1a2transfected hek293 cells that coexpressed pdzk1 or nherf1. Interpro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. Treatment of adult patients with very high elevations of serum triglyceride levels types iv and v hyperlipidemia who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort to control them. Sat1 null mice also exhibit hyperoxalemia, hyperoxaluria and calcium oxalate urolithiasis. It plays a key role in the disposition and hepatic clearance of mostly cationic drugs and endogenous compounds. Interaction of organic cations with organic anion transporters. A, transportermediated clearance of 3 hlabeled estrone 3sulfate es, cimetidine, and 1mpp was calculated as the clearance in injected oocytes minus the clearance of uninjected oocytes.
This gene is a member of a family of sulfateanion transporter genes. Hotchkiss, tiandai gao, usman khan, liam berrigan, mansong li, leslie ingraham, and ryan m. Expression profiling of solute carrier gene families at. Organic anion transporter 3 contributes to the regulation. Pineda m, fernandez e, torrents d, estevez r, lopez c, camps. Organic anion transporter 4 organic anion transporters. Slc26a1 gene genecards s26a1 protein s26a1 antibody. Information and translations of organic anion transporters, sodiumindependent in the most comprehensive dictionary definitions resource. Oat1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the. Slc3a2 4f2hc for insertion into the plasma membrane torrents et al. A threedimensional model of human organic anion transporter 1. Phylogentically, organic anion transporter oat1 and oat3 are closely related, whereas oat2 is more distant. Organic anion transporter 1 is inhibited by multiple mechanisms and shows a transport mode independent of exchanges adam g. If slc26a11 regulates sulfate availability in the csf, it may.
The anion exchanger sat1 sulfate anion transporter 1 slc26a1 is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain undetermined. Lamotrigine, tablet, 200 mg1, oral, torrent pharmaceuticals limited, 20090127, not applicable, us us. Organic cation transporter 1 how is organic cation. Experiments with human embryonic kidney293 cells stably transfected with human oat1, oat2, or oat3 were performed to compare selected transport properties. The prototypic organic anion transporter ligand bsp and the bile acid tc had little. Slco3a1 solute carrier organic anion transporter family member 3a1 heterocephalus glaber naked molerat. The measurements were performed in a single experiment using the same group of oocytes. Druginduced nephrotoxicity still hampers drug development, because current translation from in vitro or animal studies to human lacks high predictivity. Come and experience your torrent treasure chest right here. Looking for online definition of organic anion transporter f in the medical dictionary. Organic anion transporter 4 organic anion transporters oats. Structural basis for amino acid transport by the cat family of slc7.
James,c niels sandal,d jens stougaard,d masayoshi kawaguchi,e ai miyamoto,f norio suganuma,f and michael k. Organic anion transporter 1 oat1,9,10 a gene originally identified as novel kidney transporter nkt and proposed to function in organic ion received february, 2008. First isolated in 1997 from rat kidney using xenopus oocyte expression assay, organic anion transporter 1 oat1 was demonstrated to mediate the accumulation of paminohippurate, the prototypical organic anion used to study renal organic anion transport sekine et al. Mediates sulfate transport with high affinity pubmed. Interactions of human organic anion as well as cation. Organic anion transporter 1 is inhibited by multiple. Oct1 is primarily a hepatic uptake transporter, expressed on the sinusoidal membrane blood side of hepatocytes. Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including a host of widely prescribed drugs. Slco1b3 belongs to the organic anion transporter oatp family. Organic cation transporter 2 oct2 straight healthcare. The slc26 gene family of anion transporters and channels. Characterization of the human sulfate anion transporter hsat1. Novel liverspecific organic anion transporter oat7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Cao mj1, wang z, wirtz m, hell r, oliver dj, xiang cb.
We examined the substrate specificity of human organic anion transporter hoat 1 and hoat3 for various cephalosporin antibiotics, cephaloridine, cefdinir, cefotiam, ceftibuten, cefaclor, ceftizoxime, cefoselis and cefazolin by using hek293 cells stably transfected with hoat1 or hoat3 cdna hekhoat1, hekhoat3. Organic anion transporter 1 an overview sciencedirect. Anti human organic anion transporter 1 oat1 polyclonal. Novel liverspecific organic anion transporter oat7 that operates the. Identification of a membrane protein, lat2, that coexpresses with. Canalicular multispecific organic anion transporter 1. The current study aimed to establish a robust and a more complete human cell model suitable for screening of drugrelated interactions and.
Organic anion transporter polypeptiderelated protein 2. Major role of organic anion transporter 3 in the transport. Effects of indoxyl sulfate on organic anion uptake mediated by humanoats and ratoat2, and organic cation uptake mediated by humanocts. Sulphate abc transporter, permease protein cysw ipr011866. In biology, an ion transporter or ion pump is a transmembrane protein that moves ions across a biological membrane against their concentration gradient through active transport. Ion transporter definition of ion transporter by the. Pdzk1 and nherf1 regulate the function of human organic. Borsani g, reig n, fernandez e, estevez r, pineda m, torrents d, camps m, lloberas j, zorzano a, palacin m september 1999. Slco1a2 solute carrier organic anion transporter family. Organic anion transporter 3 and organic anion transporting polypeptides 1b1 and 1b3mediated transport of catalposide hyeonuk jeong,1 mihwa kwon,2 yongnam lee,3 ji seok yoo,3 dae hee shin,3 imsook song,2 hye suk lee1 1college of pharmacy, the catholic university of korea, bucheon 420743, korea. Slc21a9, which transports estrone3sulfate,38,39 has been reported to be. The sulfate transporter is a solute carrier family protein that in humans is encoded by the slc26a2 gene. Both tm1 and tm6 are broken in the centre of the transporter to form. Chondroitin sulfate, lamotrigine may decrease the excretion rate of chondroitin.
All of the nsaids tested inhibited 14cpah uptake via oat1 expressed in xenopus laevis oocytes. Organic anion transporters oats play an essential role in the elimination of numerous endogenous and. Physiological roles of mammalian sulfate transporters nas1. Slc26a1 solute carrier family 26 member 1 is a protein coding gene. It is a member of the organic anion transporter oat family of proteins.
Whereas cat1 functions to supply cationic amino acids for cellular. Human organic anion transporter 2 is distinct from organic. Whereas in humans and the great apes, uric acid is the end product of purine degradation, in other mammals, it is further degraded into allantoin by uricase, an enzyme that is mostly found in the liver. Often, renal adverse effects are recognized only during clinical stages of drug development. Protein ontology mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17betaestradiol 17glucosiduronic acid and leukotriene c4 pmid. Characterization of the human sulfate anion transporter hsat1 protein and gene sat1. Slc26asulp transporter domain ipr011547 oats are nonselective transporters prominent in the kidney, placenta and bloodbrain barrier. Circulating sulfate levels are maintained by the nas1 sulfate transporter,which is expressed in the kidneywhere it facilitates renal sulfate reabsorption. Slco3a1 solute carrier organic anion transporter family. Pelis department of pharmacology, dalhousie university, halifax, nova scotia, canada received may 27, 2015.
This gene is primarily expressed in the liver, pancreas, and brain. Role of bloodbrain barrier organic anion transporter 3 oat3 in the efflux of indoxyl sulfate, a uremic toxin. We couldnt find direct synonyms for the term organic cation transporter 1. Ion transporter synonyms, ion transporter pronunciation, ion transporter translation, english dictionary definition of ion transporter. Yohannes hagos, interaction of organic anion transporter 2 oat2 and sodium taurocholate cotransporting polypeptide ntcp with antineoplastic compounds, pharmacol res. Targets 17enzymes 2carriers 1transporters 3biointeractions 25. Exhibits sodiumindependent sulfate anion transporter activity that may. Naohiko anzai 1, yoshikatsu kanai 1, hitoshi endou 1 2 1 department of pharmacology and toxicology, kyorin university school of medicine, japan 2 fuji biomedix co.
Sulfate is involved in manymetabolic and cellular processes, and is essential for normal growth and development. What does organic anion transporters, sodiumindependent mean. The organic anion transporter 1 oat1 also known as solute carrier family 22 member 6 slc22a6 is a protein that in humans is encoded by the slc22a6 gene. Substrate estrone3sulfate uptake by oatp1a2 was significantly increased to. Three splice variants that encode different isoforms have been identified. Smt15 belongs to a previously uncharacterized subfamily of putative membranelocalized sulfateanion transporters that contain a sulfate transporter domain and are found in a widely distributed subset of eukaryotes and bacteria. Molecular mechanisms for species differences in organic anion transporter 1, oat1. Defects in a new class of sulfateanion transporter link. Key role for the organic anion transporters, oat1 and oat3.
Oat1 organic anion transporter 1 slc22a6 c show summary. Oatps are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues mikkaichi et al. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool. Small molecular drug transfer across the bloodbrain barrier via. Nas1 sulfate transporter,hyposulfataemia and autism 1 h. Relevance of copper transporter 1 and organic cation. Review of organic cation transporter 2 oct2 including list of inducers, inhibitors, and substrates. Nas1 and sat1 encode renal anion transporters that mediate proximal tubular sulfate reabsorption and thereby regulate blood sulfate levels. Molybdate transport through the plant sulfate transporter. Common to oat1, oat2, and oat3 is their ability to transport cgmp.
Thyroid hormone transport by the heterodimeric human system l. The water molecule or sodium ion appears to stabilise the unwound. Slco1c1 is thought to play a major role in regulating t4 flux in the brain. The sulfate transporter sst1 is crucial for symbiotic. The anion exchanger sat1 sulfate anion transporter 1 slc26a1 is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain. Transport of estrone 3sulfate mediated by organic anion transporter oatp4c1. The expression and activity of these transporters is influenced by several conditions, including transcriptional regulation, genderdependent regulation, and genetic variation. In kidney, oats are responsible for extracting potentially toxic endogenous and exogenous molecules from plasma and delivering them to the tubular lumen for excretion in urine. Zou l, stecula a, gupta a, prasad b, chien hc, yee sw, wang l, unadkat jd, stahl sh, fenner ks, giacomini km. Na independent neutral amino acid transporter lat1.
Transport properties of nonsteroidal antiinflammatory. Members of the organic anion transporter oat 2 family mediate transport of anionic drugs, toxins, and other xenobiotics across excretory and barrier tissues. Slc26a1 sulfate anion transporter 1 homo sapiens human. Organic anion transporter polypeptiderelated protein 1. Distribution of expression profiles for slc genes in the choroid plexus cp. Organic anion transporter 1 how is organic anion transporter 1 abbreviated. Slco3a1 solute carrier organic anion transporter family member 3a1 chlorocebus sabaeus african green monkey. Slco1a2 solute carrier organic anion transporter family member 1a2, authors.
Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of. A canalicular multispecific organic anion transporter 1 that is encoded in the genome of human. Family members are well conserved in their genomic number and size of. The sulfate permease sulp family is a member of the large apc superfamily of secondary carriers. Targeted disruption of murine nas1 and sat1 leads to hyposulfatemia and hypersulfaturia.
An enigmatic human solute carriers hong shen, yurong lai, and a. The present study investigated whether or not nonsteroidal antiinflammatory drugs nsaids are transported by oat1. Family members are well conserved in their genomic number and size of exons and protein aa length among species structures, but have markedly different tissue expression patterns. The aim of this study was to investigate the relevance of copper transporter 1 ctr1 and organic cation transporters oct for oxaliplatin uptake and resistance to the drug in sensitive and oxaliplatinresistant ileocecal colorectal adenocarcinoma cells. Human organic anion transporter 1oat1 encodes a 563 amino acid residue protein, and which is predicted 12 putative membranespanning protein. Lopid gemfibrozil tablets, usp is indicated as adjunctive therapy to diet for. Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney article in kidney international 615. Human oat1 was found to be expressed predominantly in the kidney and only weakly in the brain. Absence of the sulfate transporter sat1 has no impact on. The sulp family is a large and ubiquitous family of proteins derived from archaea, bacteria, fungi, plants and animals.
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